منابع مشابه
Prion infection of oral and nasal mucosa.
Centrifugal spread of the prion agent to peripheral tissues is postulated to occur by axonal transport along nerve fibers. This study investigated the distribution of the pathological isoform of the protein (PrP(Sc)) in the tongues and nasal cavities of hamsters following intracerebral inoculation of the HY strain of the transmissible mink encephalopathy (TME) agent. We report that PrP(Sc) depo...
متن کاملEvaluation of the Safety and Toxicological Profile of MucoLox: Human Oral Mucosa, Nasal Mucosa and Vaginal Mucosa (Part 2/3)
Introduction: The nasal cavity is a promising site for drug delivery as it is easily accessible to patients, has a large surface area (due to the presence of microvilli), contains a thin nasal epithelium, and it can bypass first-pass metabolism [1]. However, many conventional dosage forms (e.g. gels, solutions, suspensions) have low residence time (time at site of action) within the nasal cavit...
متن کاملEvaluation of the Safety and Toxicological Profile of MucoLox: Human Oral Mucosa, Nasal Mucosa and Vaginal Mucosa (Part 3/3)
Introduction: Vaginal delivery of medication is advantageous in allowing for the medication to avoid first-pass metabolism and gastrointestinal degradation [1]. Lined with non-cornified, stratified squamous epithelium, the vaginal mucosa offers a large surface area and rich blood supply, making it a promising site for delivery of medication in the treatment of conditions such as vaginitis (infl...
متن کاملEvaluation of the Safety and Toxicological Profile of MucoLox: Human Oral Mucosa, Nasal Mucosa and Vaginal Mucosa (Part 1/3)
Introduction: The buccal mucosa, which contains non-keratinized epithelial cells lining the inner cheeks of the mouth, is a site for local and systemic delivery of medication. This region is highly vascularized and relatively immobile [1]. Buccal delivery allows for the active ingredients to exert rapid onset of action, bypassing liver first pass-metabolism, and avoiding pH fluctuations and deg...
متن کاملThe Fungi Flora of Healthy Nasal Mucosa in Kerman, Iran
Introduction: Environmental fungi, molds and yeasts, can infest the nasal cavity through inhaled air. There is some evidence that they could be the main cause of Chronic Rhinosinusitis (CRS) but little is known about the normal fungal flora in the human nose. The objective of this study was to assess the normal fungal flora of the nasal mucus in adults in Kerman. Materials and Methods: We ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2006
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.80.9.4546-4556.2006